10.1/2(M/AM/C) (f) BIO-INFORMATICS
UNIT-I
[1] Introduction: Definitions, Sequencing, Biological sequence/structure, Genome
Projects, Pattern recognition an prediction, Folding problem, Sequence Analysis, . Homology and Analogy
[1] Protein Information Resources Biological databases, Primary sequence databases, Protein Sequence databases, Secondary databases, Protein pattern databases, and Structure classification databases.
UNIT-II
[2] Genome Information Resources DNA sequence databases, specialized genomic resources
[3] DNA Sequence analysis Importance of DNA analysis, Gene structure and DNA sequences, Features of DNA sequence analysis, EST (Expressed Sequence Tag) searches, Gene hunting, Profile of a cell, EST analysis, Effects of EST data on DNA databases
UNIT-III
[4] Pair wise alignment techniques Database searching, Alphabets and complexity, Algorithm and programs, Comparing two sequences, sub-sequences, Identity and similarity, The Dot plot, Local and global similarity, different alignment techniques, Dynamic Programming, Pair wise database searching.
[5] Multiple sequence alignment Definition and Goal, The consensus, computational complexity, Manual methods, Simultaneous methods, Progressive methods, Databases of Multiple alignments and searching
UNIT-IV
[6] Secondary database searching Importance and need of secondary database searches, secondary database structure and building a sequence search protocol
[7] Analysis packages Analysis package structure, commercial databases, commercial software, comprehensive packages, packages specializing in DNA analysis, Intranet Packages, Internet Packages.
Text Books:
1 Introduction to Bioinformatics, T K Attwood & D J Parry-Smith Addison Wesley
2 Bioinformatics- A Beginner’s Guide, Jean-Michel Claveriw, Cerdric Notredame WILEY dreamlech India Pvt. Ltd
Reference Books:
[1] Introduction to Bioinformatics, Arthur M.Lesk, OXFORD publishers (Indian Edition)
For more details, visit http://www.nannayauniversity.info/courses.html
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