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Posted Date: 27 Jun 2008 Posted By: amit Member Level: Gold
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2007 Birla Institute of Technology-Mesra B.E Molecular Immunology University Question paper
Birla Institute of Technology and Science, Pilani.
Molecular Immunology ( BioG514)
Comprehensive Examination (Open book)
M.marks 30 Time 3 hrs.
1. Why is the diversity of the ?d T-Cell repertoire theoretically greater than the aß T-cell repertoire? Why is the actual diversity limited compared to the aß T-cell repertoire? (3)
2. What is the phenomenon that every B-cell can have only one specificity? (3)
3. In neonatal mice, some B-cells originate mostly from the foetal liver. These are different from normal B-cells. Explain with characteristics. (3)
4. Do knockout mice lack plasma MHC expression give rise to ++Thymocytes? What is that they can’t produce & why? (3)
5. What could happen in T-Cell signaling if ZAP became mutated? (3)
6. How can complement help in removal of microbes? (3)
7. What is the role of FceR1 molecules in hypersensitivity? (3)
8. What is the role of adhesion molecules in autoimmune disorders? Are Cytokines involved?? (3)
9. What is the ? chain associated with the T-cell and what is its significance? (3)
10. Explain the concept of affinity maturation? (3)
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